US Central Command, which oversees American military operations in the region, said aircrews successfully completed the mission on Saturday.
Earlier reports in Israeli media said two of the giant aircraft were seen flying over Israel.
Gen. Frank McKenzie, Central Command’s commander, said such missions are ways to demonstrate the US military’s continuing commitment to regional security.
“Short-term deployments of strategic assets are an important part of our defensive posture in the region,” he said. “The training opportunity and continued integration with regional partners improves readiness and delivers a clear and consistent message in the operational environment to both friends and potential adversaries, alike.”